![]() ![]() The study selection process yielded a total of 45 studies. All randomized clinical trials, meta-analyses, observational studies, and placebo-controlled trials regarding trazodone for the treatment of primary or secondary insomnia were reported, per PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. The results were restricted to English language and human subjects. METHODS: A literature search was conducted using MEDLINE/PubMed databases from the past 33 years (1983-2016) and the keywords insomnia, trazodone, sedative, treatment, and hypnotics. In this systematic review, we examined the evidence for the efficacy and safety of trazodone for insomnia. Quviviq vs.OBJECTIVE: While trazodone is approved for the treatment of depression, the off-label use of this medication for insomnia has surpassed its usage as an antidepressant.Can you take hydroxyzine for anxiety and sleep?.How do I use prescription sleeping pills safely?.How long does it take for trazodone to work?.How long does trazodone stay in your system?.National Library of Medicine MedlinePlus. Review of Safety and Efficacy of Sleep Medicines in Older Adults. Schroeck JL, Ford J, Conway EL, et al.DESYREL® (trazodone hydrochloride) tablets, for oral use. Trazodone for Insomnia: A Systematic Review. ![]() Update on the safety considerations in the management of insomnia with hypnotics: incorporating modified-release formulations into primary care. Clinical practice guideline for the pharmacologic treatment of chronic insomnia in adults: an American Academy of Sleep Medicine clinical practice guideline.
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